Listen to a Podcast About Addiction Science

Understand the neuroscience of addiction — dopamine pathways, reward circuitry, tolerance, withdrawal, and the evidence-based treatments transforming recovery from substance use disorders.

The National Institute on Drug Abuse (NIDA) reclassified addiction as a chronic brain disorder rather than a moral failing in the 1990s, based on neuroimaging studies showing persistent changes in the prefrontal cortex and mesolimbic dopamine system. The U.S. opioid epidemic, declared a public health emergency in 2017, has claimed over 500,000 lives since 1999, with the crisis traced partly to Purdue Pharma's aggressive marketing of OxyContin beginning in 1996. Medication-assisted treatment (MAT) using drugs like buprenorphine and naltrexone has been shown to reduce opioid overdose deaths by 50% and increase treatment retention rates, yet only about 20% of people with opioid use disorder receive MAT due to stigma and regulatory barriers.

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