Listen to a Podcast About DNA & Genetics

Explore the molecule of life — how DNA encodes genetic information, the mechanics of heredity, gene expression, CRISPR gene editing, and the future of personalized medicine.

James Watson and Francis Crick published the double-helix structure of DNA in April 1953, building on critical X-ray crystallography work by Rosalind Franklin — a discovery so fundamental it earned the 1962 Nobel Prize and launched the era of molecular biology. Fifty years later, the Human Genome Project was completed in 2003 after 13 years and $2.7 billion, sequencing all 3.2 billion base pairs of human DNA; today, the same sequencing can be done for under $200 in a matter of hours. The 2012 discovery of CRISPR-Cas9 gene editing by Jennifer Doudna and Emmanuelle Charpentier added a precise molecular scalpel to the toolkit, enabling targeted modifications to DNA that are already being used in clinical trials for sickle cell disease, certain cancers, and hereditary blindness.

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